A stochastic π-calculus model of MHC class I antigen presentation
نویسنده
چکیده
3 Modelling 5 3.1 Basic model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3.1.1 Stochastic π-calculus implementation . . . . . . . . . . . . 5 3.1.2 Model parameters and discussion . . . . . . . . . . . . . . 8 3.1.3 Simulation results . . . . . . . . . . . . . . . . . . . . . . 10 3.2 Flytrap model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 3.2.1 Stochastic π-calculus implementation . . . . . . . . . . . . 13 3.2.2 Model parameters and discussion . . . . . . . . . . . . . . 17 3.2.3 Simulation results . . . . . . . . . . . . . . . . . . . . . . 19 3.3 Time-dependent optimization of peptide repertoire . . . . . . . . 20 3.3.1 Simulation results . . . . . . . . . . . . . . . . . . . . . . 20 3.3.2 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 3.4 Model testing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 3.4.1 MHC class I heavy chain alleles . . . . . . . . . . . . . . . 23 3.4.2 Model fitting . . . . . . . . . . . . . . . . . . . . . . . . . 24
منابع مشابه
SUSCEPTIBILITY OF HUMAN WM MELANOMA CELL LINES TO NK AND LAK CYTOTOXICITY AND THEIR RELEVANCE TO THE LEVEL OF MHC CLASS I AND ICAM-l ANTIGEN EXPRESSION
The effect of natural killer (NK) cells and lymphokine activated killer ( LAK) cells was studied on a group of human melanoma cell lines. Peripheral blood from healthy volunteers was utilized as a fresh source of natural killer cells and rhI L-2 for producing LAK cells. The cytotoxicity of effector cells was quantified using a 4 hour SI determining the density of antigen expression on tumor...
متن کاملپیشرفت های جدید در شناخت اسپوندیلوآرتروپاتی ها
In last few years, numerous observations and studies on pathogenesis of spondyloarthropathies have been published and an animal model which confirms the associations of new information is now available. Bacteria which are responsible for reactive arthritis all can remain in the cells for long time. Molecules of class I MHC are able to present the intracellular peptides to immune system. B27 mol...
متن کاملLectins Isolated from Mushroom Fomitella fraxinea Enhance MHC-restricted Exogenous Antigen Presentation
Background: Immunomodulators enhancing MHC-restricted antigen presentation would affect many cellular immune reactions mediated by T cells or T cell products. However, modulation of MHC-restricted antigen presentation has received little attention as a target for therapeutic immunoregulation. Here, we report that lectins isolated from mushroom Fomitella fraxinea enhance MHC-restricted exogenous...
متن کاملIsolation and purification of HLA-DR antigen from Daudi cell line by immunoaffinity chromatography
Introduction: The major histocompatibility complex (MHC) is a group of cell surface proteins that are essential for recognizing foreign molecules in human and other mammals. The physiologic function of MHC molecules is the presentation of peptides to T cells. In this study, we evaluated the purification of a class II MHC molecule (HLA-DR) from a human Burkitt′s lymphoma cell line; Daudi...
متن کاملAcute Pharmacologic Degradation of a Stable Antigen Enhances Its Direct Presentation on MHC Class I Molecules
Bifunctional degraders, also referred to as proteolysis-targeting chimeras (PROTACs), are a recently developed class of small molecules. They were designed to specifically target endogenous proteins for ubiquitin/proteasome-dependent degradation and to thereby interfere with pathological mechanisms of diseases, including cancer. In this study, we hypothesized that this process of acute pharmaco...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2005